<strike id="gegfc"><dl id="gegfc"></dl></strike>
<sub id="gegfc"></sub>

    <mark id="gegfc"></mark>

      Mitochondrial dysfunction contributes to kidney disease: study

      Source: Xinhua| 2018-06-10 03:42:14|Editor: yan
      Video PlayerClose

      CHICAGO, June 9 (Xinhua) -- Researchers at Northwestern University (NU) have identified a receptor that causes kidney dysfunction when suppressed, linking mitochondria with kidney disease.

      They found in the study that the receptor, estrogen-related receptor (ERR) gamma, not only directly regulates kidney mitochondrial metabolism but also controls the abundance of renal solute carriers and pumps with another transcription factor called HNF1 beta. Deletion of ERR gamma results in kidney dysfunction comparable to that seen in models with loss-of-function mutations in HNF1 beta, which supports link between ERR gamma and HNF1 beta.

      ERR gamma is a critical molecule linking energy-producing and energy-consuming functions in the kidney. It was found in unusually low levels in patients with chronic kidney disease, pointing to its importance in healthy kidney function.

      Mitochondria are the power plants of the cell, breaking down nutrients and converting them to chemical energy used in a variety of processes. Mutations in mitochondria can reduce their effectiveness, causing dysfunction in organs with high energetic demand such as the heart or kidneys.

      The study, released on NU's website Thursday, has been published in Proceedings of the National Academy of Sciences.

      TOP STORIES
      EDITOR’S CHOICE
      MOST VIEWED
      EXPLORE XINHUANET
      010020070750000000000000011105521372430571
      中文字幕日韩无线码在线一区_制服肉丝亚洲中文字幕_日韩欧美无砖专区一中文字目_国产精品点击进入在线影院高清
      <strike id="gegfc"><dl id="gegfc"></dl></strike>
      <sub id="gegfc"></sub>
      
      
        <mark id="gegfc"></mark>
          尤物在线一区二区三区 | 中文字幕不卡在线 | 亚洲综合精品第一页国产亚洲 | 亚洲欧美日韩一区 | 免费国产真实迷jian系列网址 | 久久免费视频77 |